H-2K与H-2D产物之间的交叉反应性。III. H-2K-H-2D交叉致敏对皮肤移植存活的影响。

Cross reactivity between H-2K and H-2D products. III. Effect of H-2K-H-2D cross sensitization on skin graft survival.

作者信息

Murphy D B, Shreffler D C

出版信息

Transplantation. 1975 Jul;20(1):38-44. doi: 10.1097/00007890-197507000-00006.

DOI:10.1097/00007890-197507000-00006

PMID:52220

Abstract

Cross sensitization between the products of the H-2K and H-2D loci has been demonstrated by an experimental design in which recipients were sensitized with tissue bearing determinants controlled by one locus (e.g., H-2K), and then challenged with skin grafts expressing determinants controlled by the other locus (e.g., H-2D). In one combination, experimental grafts were rejected faster than first-set control grafts. Cellular rather than humoral mechanisms appeared to mediate this effect. In a second combination, prolonged survival of experimental grafts were observed. This enhanced survival may have been influenced by serum antibody, either to H-2 or Ia determinants.

摘要

H-2K和H-2D位点产物之间的交叉致敏已通过一项实验设计得到证实，在该实验设计中，受体先用携带由一个位点（如H-2K）控制的决定簇的组织进行致敏，然后用表达由另一位点（如H-2D）控制的决定簇的皮肤移植物进行攻击。在一种组合中，实验移植物的排斥比初次对照移植物更快。细胞机制而非体液机制似乎介导了这种效应。在第二种组合中，观察到实验移植物的存活时间延长。这种存活时间的延长可能受到针对H-2或Ia决定簇的血清抗体的影响。

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Cross reactivity between H-2K and H-2D products. III. Effect of H-2K-H-2D cross sensitization on skin graft survival.H-2K与H-2D产物之间的交叉反应性。III. H-2K-H-2D交叉致敏对皮肤移植存活的影响。

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