H-2K与H-2D产物之间的交叉反应性。I.广泛且相互的血清学交叉反应性的证据。
Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity.
作者信息
Murphy D B, Shrefler D C
出版信息
J Exp Med. 1975 Feb 1;141(2):374-91. doi: 10.1084/jem.141.2.374.
Abstract
Serological cross-reactivity between the products of the H-2K and H-2D genes has been demonstrated by a design in which antibody was produced against determinants controlled by one locus (e .g . H-2K(k)), and then tested against the product of the opposite locus (e .g . H-2D(d)). A total of 13 out of 18 such test combinations exhibited H-2K-H-2D cross-reactivity. The presence or absence of cross-reactivity was reciprocal in most cases (i.e. antibody directed against the H-2K(k) gene product reacted with H-2(d) determinants, and antibody directed against the H-2D(d) gene product reacted with H-2K(k) determinants). An Ia-like reaction was detected with one antiserum which implied possible cross-reactivity between the products of two discrete la genes.
摘要
通过一种设计已证明H - 2K和H - 2D基因产物之间存在血清学交叉反应，该设计是产生针对由一个位点（如H - 2K(k)）控制的决定簇的抗体，然后针对相对位点的产物（如H - 2D(d)）进行检测。在18个这样的测试组合中，共有13个表现出H - 2K - H - 2D交叉反应。在大多数情况下，交叉反应的存在与否是相互的（即针对H - 2K(k)基因产物的抗体与H - 2(d)决定簇反应，针对H - 2D(d)基因产物的抗体与H - 2K(k)决定簇反应）。用一种抗血清检测到了类似Ia的反应，这意味着两个离散的Ia基因产物之间可能存在交叉反应。
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