Madrazo J L, López J, González C, Casado de Frías E
An Esp Pediatr. 1976 Mar-Apr;9(2):121-9.
Cord serum AFP levels have been determined in 66 newborn samples, between 30 to 42 weeks of gestational age. Results showed some relation between AFP rate and newborn maturity degree, so it was possible to foresay the gestational age with some limits of error +/- 17 days in full-term newborn, and +/- 10 days in premature ones. Cuantification in the amniotic fluid of 18 high risk gestation gave normal AFP rates. AFP of thirty patients with respiratory distress was tested. An AFP increase was present in 14 of 15 cases of hyaline membrane. On the remaining 15 cases of respiratory distress only 3 gave high levels. These facts point that AFP can be used as a suitable parameter in the biochemical diagnosis of hyaline membrane.
已对66例胎龄在30至42周之间的新生儿样本测定了脐血甲胎蛋白（AFP）水平。结果显示AFP水平与新生儿成熟度之间存在一定关系，因此有可能在一定误差范围内预测胎龄，足月儿误差为±17天，早产儿误差为±10天。对18例高危妊娠的羊水进行定量检测，AFP水平正常。对30例呼吸窘迫患者的AFP进行了检测。15例透明膜病患者中有14例AFP升高。在其余15例呼吸窘迫患者中，只有3例AFP水平升高。这些事实表明，AFP可作为透明膜病生化诊断的合适参数。
