苦杏仁苷：毒性、抗癌活性及其在植物种子中测定的分析方法。
Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds.
机构信息
Department of Analytical Chemistry, Faculty of Chemistry, Gdansk University of Technology, 11/12 Narutowicza Str., 80-233 Gdansk, Poland.
Division of Organic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland.
出版信息
Molecules. 2021 Apr 13;26(8):2253. doi: 10.3390/molecules26082253.
Amygdalin (d-Mandelonitrile 6--β-d-glucosido-β-d-glucoside) is a natural cyanogenic glycoside occurring in the seeds of some edible plants, such as bitter almonds and peaches. It is a medically interesting but controversial compound as it has anticancer activity on one hand and can be toxic via enzymatic degradation and production of hydrogen cyanide on the other hand. Despite numerous contributions on cancer cell lines, the clinical evidence for the anticancer activity of amygdalin is not fully confirmed. Moreover, high dose exposures to amygdalin can produce cyanide toxicity. The aim of this review is to present the current state of knowledge on the sources, toxicity and anticancer properties of amygdalin, and analytical methods for its determination in plant seeds.
苦杏仁苷（d-苦杏仁腈-β-D-吡喃葡萄糖苷-β-D-吡喃葡萄糖苷）是一种天然的氰苷，存在于某些食用植物的种子中，如苦杏仁和桃子。它是一种具有医学意义但有争议的化合物，一方面具有抗癌活性，另一方面可通过酶解和产生氢氰酸而产生毒性。尽管在癌细胞系方面有很多研究，但苦杏仁苷的抗癌活性的临床证据尚未完全证实。此外，高剂量暴露于苦杏仁苷可产生氰化物毒性。本文综述了苦杏仁苷的来源、毒性和抗癌特性，以及植物种子中苦杏仁苷的分析方法，旨在介绍目前对苦杏仁苷的认识。
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