Almér L O, Nilsson I M
Acta Med Scand. 1975 Jul-Aug;198(1-2):101-6. doi: 10.1111/j.0954-6820.1975.tb19512.x.
In diabetics, irrespective of age at onset and standing of the disease, the fibrinolytic activity in the blood is decreased, most markedly in obese patients and in those with angiopathy. In this investigation we found--significantly more often than in controls--a low release of the plasminogen activator to the blood from the endothelial cells, and also in one fourth of the diabetics an abnormally low activator activity of the vessel walls. These changes, as well as the significantly elevated levels of inhibitors of the fibrinolytic activity, will impair removal of fibrin deposits and possibly contribute to the development of vascular lesions.
在糖尿病患者中，无论发病年龄和病程长短，血液中的纤溶活性均降低，在肥胖患者和患有血管病变的患者中最为明显。在本研究中，我们发现——比对照组更频繁且显著地——内皮细胞向血液中释放纤溶酶原激活物的量较低，并且四分之一的糖尿病患者血管壁的激活物活性异常低。这些变化，以及纤溶活性抑制剂水平的显著升高，将损害纤维蛋白沉积物的清除，并可能促成血管病变的发展。
