Almér L O
J Med. 1975;6(5-6):351-67.
Examination of the fibrinolytic system of 221 diabetics with varying grades of under- and overweight revealed not only an elevated fibrinogen level and a significantly decreases spontaneous and stimulated fibrinolytic activity in obesity, but also a highly significantly decreased activity of plasminogen activator of the vessel walls in these patients. Similar, but less marked, changes were found in obese non-diabetics. Thes changes imply a decreased ability to remove fibrin deposits within the lumina of small and large vessels and thus an increased risk of thrombosis, and they may be closely related to the high frequency of late complications in diabetes mellitus.
对221名不同程度超重和肥胖的糖尿病患者的纤溶系统进行检查发现，不仅肥胖患者的纤维蛋白原水平升高，自发和刺激后的纤溶活性显著降低，而且这些患者血管壁纤溶酶原激活剂的活性也高度显著降低。在肥胖的非糖尿病患者中也发现了类似但不太明显的变化。这些变化意味着清除大、小血管腔内纤维蛋白沉积物的能力下降，从而增加了血栓形成的风险，它们可能与糖尿病晚期并发症的高发生率密切相关。
