三甲丙咪嗪对大鼠血小板功能和组胺释放的影响。
The effect of Trimepranol on thrombocyte function and histamin release in the rat.
作者信息
Nosal R, Menyhardtová Z
出版信息
Agents Actions. 1975 Feb;5(1):9-14. doi: 10.1007/BF02027151.
PMID:52290
Abstract
Trimepranol a beta adrenergic blocking drug released serotonin from rat isolated and plasma-rich thrombocytes in vitro. The release was time- and dose-dependent. With the same concentrations this drug inhibited the histamine release from isolated rat mast cells. Aggregation of isolated or plasma-rich thrombocytes induced by ADP was inhibited by Trimepranol. The inhibition was dose, time dependent and reversed by calcium ions.
摘要
曲美托洛尔是一种β肾上腺素能阻断药物，在体外可使大鼠分离的富含血浆的血小板释放5-羟色胺。这种释放具有时间和剂量依赖性。在相同浓度下，该药物可抑制大鼠分离肥大细胞释放组胺。曲美托洛尔可抑制由二磷酸腺苷诱导的分离的或富含血浆的血小板聚集。这种抑制具有剂量和时间依赖性，并可被钙离子逆转。
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