Famaey J P, Fontaine J, Seaman I, Reuse J
Naunyn Schmiedebergs Arch Pharmacol. 1979 Nov;309(2):191-5. doi: 10.1007/BF00501228.
High concentrations of antiinflammatory steroids (2.5-40 microgram/ml) reversibly inhibited the electrically induced contractions of the guinea-pig isolated ileum. At 40 microgram/ml they also reversibly inhibited contractions elicited by acetylcholine, histamine nicotine and 5-hydroxytryptamine. PGE1 (2.5 ng/ml), PGE2 (2.5 ng/ml) and PGF 2 alpha (25 ng/ml) antagonized these effects. The inhibition of contractions elicited by direct agonists were less pronounced than those elicited by indirect or partly indirect agonists. The inhibitory effect of steroids may be related to non-specific actions on biological membranes. An overall sensitization of the smooth muscle by PG's may explain their antagonism to inhibition by steroids.
高浓度的抗炎类固醇（2.5 - 40微克/毫升）可可逆地抑制豚鼠离体回肠的电诱导收缩。在40微克/毫升时，它们也可可逆地抑制由乙酰胆碱、组胺、尼古丁和5 - 羟色胺引起的收缩。前列腺素E1（2.5纳克/毫升）、前列腺素E2（2.5纳克/毫升）和前列腺素F2α（25纳克/毫升）可拮抗这些作用。直接激动剂引起的收缩抑制比间接或部分间接激动剂引起的收缩抑制作用不那么明显。类固醇的抑制作用可能与对生物膜的非特异性作用有关。前列腺素对平滑肌的总体致敏作用可能解释了它们对类固醇抑制作用的拮抗。
