Concerning the mechanism of action of interferon.
作者信息
Joklik W K, Merigan T C
出版信息
Proc Natl Acad Sci U S A. 1966 Aug;56(2):558-65. doi: 10.1073/pnas.56.2.558.
Abstract
摘要
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Concerning the mechanism of action of interferon.关于干扰素的作用机制。
Proc Natl Acad Sci U S A. 1966 Aug;56(2):558-65. doi: 10.1073/pnas.56.2.558.
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Interferon inhibits viral protein synthesis in L cells infected with vaccinia virus.干扰素可抑制感染牛痘病毒的L细胞中的病毒蛋白合成。
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A protein synthesizing system from interferon-treated cells that discriminates between cellular and viral messenger RNAs.一种来自经干扰素处理的细胞的蛋白质合成系统，该系统能够区分细胞信使核糖核酸和病毒信使核糖核酸。
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Inhibition of early vaccinia virus protein synthesis in interferon-treated chicken embryo fibroblasts.在干扰素处理的鸡胚成纤维细胞中早期痘苗病毒蛋白质合成的抑制作用
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Mechanism of interferon action. Species specificity of interferon and of the interferon-mediated inhibitor of translation from mouse, monkey, and human cells.干扰素作用机制。干扰素及小鼠、猴和人细胞中干扰素介导的翻译抑制剂的种属特异性。
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Molecular basis of the action of interferon.干扰素作用的分子基础。
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Effect of interferon on integrity of vaccinia virus and ribosomal RNA in infected cells.干扰素对感染细胞中痘苗病毒完整性和核糖体RNA的影响。
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Selective inhibition of viral protein accumulation in interferon-treated cells; nondiscriminate inhibition of the translation of added viral and cellular messenger RNAs in their extracts.在干扰素处理的细胞中对病毒蛋白积累的选择性抑制；对其提取物中添加的病毒和细胞信使核糖核酸翻译的非特异性抑制。
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Vaccinia-mediated rescue of encephalomyocarditis virus from the inhibitory effects of interferon.
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To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes.翻译与否：干扰素刺激基因对病毒和宿主mRNA的调控
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Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism.α/β干扰素通过一种不依赖PKR的机制抑制病毒mRNA而非细胞mRNA的帽依赖性翻译。
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Inhibition of Protein Synthesis in Cell-Free Systems from Interferon-Treated, Infected Cells: Further Characterization and Effect of Formylmethionyl-tRNA(F).干扰素处理的感染细胞无细胞系统中蛋白质合成的抑制：甲酰甲硫氨酰 - tRNA(F)的进一步特性及作用
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The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.2-5A系统：通过加速RNA降解来调节病毒和细胞过程。
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Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells.在牛痘病毒感染细胞的提取物中，干扰素介导的双链RNA依赖性蛋白激酶受到抑制。
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2-5A accumulates to high levels in interferon-treated, vaccinia virus-infected cells in the absence of any inhibition of virus replication.在没有对病毒复制进行任何抑制的情况下，2-5A在经干扰素处理、感染痘苗病毒的细胞中积累到高水平。
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Indiscriminate degradation of RNAs in interferon-treated, vaccinia virus-infected mouse L cells.在经干扰素处理、感染痘苗病毒的小鼠L细胞中RNA的非特异性降解。
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Inhibition of vaccinia mRNA methylation by 2',5'-linked oligo(adenylic acid) triphosphate.2',5'-连接的三磷酸寡聚腺苷酸对痘苗病毒mRNA甲基化的抑制作用。
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Inhibition of arbovirus protein synthesis by interferon.干扰素对虫媒病毒蛋白质合成的抑制作用。
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本文引用的文献
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The preparation and characteristics of highly purified radioactively labelled poxvirus.高纯度放射性标记痘病毒的制备及其特性
Biochim Biophys Acta. 1962 Aug 20;61:290-301. doi: 10.1016/0926-6550(62)90091-9.
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INTERFERON INHIBITION OF CYTOPLASMIC DNA ACCUMULATION IN VACCINIA VIRUS INFECTION. A RADIOAUTOGRAPHIC STUDY.
Proc Soc Exp Biol Med. 1965 Jun;119:551-3. doi: 10.3181/00379727-119-30235.
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THE REPLICATION AND COATING OF VACCINIA DNA.痘苗病毒DNA的复制与包膜化
J Mol Biol. 1964 Dec;10:452-74. doi: 10.1016/s0022-2836(64)80066-8.
4
EFFECT OF ACTINOMYCIN D AND PUROMYCIN DIHYDROCHLORIDE ON ACTION OF INTERFERON.放线菌素D和盐酸嘌呤霉素对干扰素作用的影响。
Virology. 1964 Dec;24:586-8. doi: 10.1016/0042-6822(64)90211-9.
5
INHIBITION OF INTERFERON BIOSYNTHESIS BY ACTINOMYCIN D.放线菌素D对干扰素生物合成的抑制作用。
Nature. 1964 Oct 3;204:49-51. doi: 10.1038/204049a0.
6
[DETERMINATION OF THE MOLECULAR WEIGHT OF INTERFERON BY GEL FILTRATION].[通过凝胶过滤法测定干扰素的分子量]
Biochem Z. 1964 Mar 12;339:382-9.
7
INHIBITION OF INTERFERON ACTION BY P-FLUOROPHENYLALANINE.
Nature. 1964 Jul 25;203:366-7. doi: 10.1038/203366a0.
8
MESSENGER RNA IN CELLS INFECTED WITH VACCINIA VIRUS.感染痘苗病毒的细胞中的信使核糖核酸
Proc Natl Acad Sci U S A. 1964 Apr;51(4):577-85. doi: 10.1073/pnas.51.4.577.
9
STUDIES ON THE MECHANISM OF INTERFERON ACTION. II. THE EFFECT OF INTERFERON ON SOME EARLY EVENTS IN MENGO VIRUS INFECTION IN L CELLS.干扰素作用机制的研究。II. 干扰素对L细胞中门戈病毒感染某些早期事件的影响。
Virology. 1964 Apr;22:575-9. doi: 10.1016/0042-6822(64)90079-0.
10
ROLE OF INTERFERON IN VIRAL INTERFERENCE.干扰素在病毒干扰中的作用。
Nature. 1964 Feb 22;201:848-9. doi: 10.1038/201848a0.
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