核破坏对核小体亚组分大分子组成的影响。
Effects of nuclear disruption on the macromolecular composition of nucleosome subfractions.
作者信息
Levy-Wilson B
出版信息
Nucleic Acids Res. 1979 Dec 20;7(8):2239-54. doi: 10.1093/nar/7.8.2239.
Abstract
The macromolecular composition of nucleosomal subfractions obtained by limited action of micrococcal nuclease upon trout testis chromatin has been analyzed with the purpose of comparison with the properties of transcriptionally active nucleosomal fractions derived by similar treatment of intact nuclei. The results indicate that when the native chromatin structure of intact nuclei is disrupted prior to the nuclease action, the nucleosomal subfractions that are subsequently generated have an altered composition.
摘要
为了与通过对完整细胞核进行类似处理得到的转录活性核小体组分的特性进行比较，分析了用微球菌核酸酶有限作用于鲑鱼睾丸染色质所获得的核小体亚组分的大分子组成。结果表明，当在核酸酶作用之前破坏完整细胞核的天然染色质结构时，随后产生的核小体亚组分的组成会发生改变。
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