Seidel J, Wenzel J
Pol J Pharmacol Pharm. 1979 Jul-Aug;31(4):407-12.
Qualitative and semiquantitative histochemical investigations of acetylcholinesterase after a single or repeated administration of isatin, 160 mg/kg ip once or daily for 8 consecutive days have revealed a significant decrease of the histochemical reaction for acetylcholinesterase in chronically treated rats. The cholinergic effect of isatin was tested in the electrophysiological experiment after a single dose of 160 mg/kg isatin and was partially antagonized by atropine.
对大鼠单次或重复给予异吲哚酮（160mg/kg，腹腔注射，单次或连续8天每日一次）后，对乙酰胆碱酯酶进行定性和半定量组织化学研究，结果显示，长期接受治疗的大鼠体内，乙酰胆碱酯酶的组织化学反应显著降低。在给予160mg/kg异吲哚酮单剂量后，通过电生理实验检测了异吲哚酮的胆碱能效应，该效应部分被阿托品拮抗。
