Singh B, Kumar P, Nagpaul J P, Sharma R, Bansal R C
Indian J Physiol Pharmacol. 1978 Jul-Sep;22(3):297-300.
In vivo administration of isatin (200 mg/kg) significantly lowered the activity of rat kidney alkaline phosphatase after 5 hr but enhanced the activity of rat duodenal and jejunal enzyme after 2 and 5 hr (P less than 0.01). The increased activity of the duodenal and jejunal alkaline phosphatase might be due to the induction of the enzyme by isatin.
体内给予异吲哚酮(200毫克/千克)5小时后,大鼠肾脏碱性磷酸酶的活性显著降低,但在2小时和5小时后,大鼠十二指肠和空肠酶的活性增强(P小于0.01)。十二指肠和空肠碱性磷酸酶活性的增加可能是由于异吲哚酮对该酶的诱导作用。