Kulkosky P J, Cornell N W
Pharmacol Biochem Behav. 1979 Oct;11(4):439-44. doi: 10.1016/0091-3057(79)90121-7.
Hamsters, as previously reported, demonstrated greater ethanol intake and preference than rats. However, as ethanol was gradually added to a sweet solution, hamster ethanol intakes did not consistently exceed ethanol metabolic capacity for prolonged periods. In ethanol-naive hamsters and rats, alcohol dehydrogenase activities and ethanol metabolic rates of isolated hepatocytes in vitro and blood ethanol elimination rates in vivo show consistent large interspecific differences corresponding to the species' differences in ethanol intake and preference. The data suggest a limiting role of ethanol metabolism in the regulation of maximized free-selection ethanol intake by rodents, and provide an explanation for the absence of continuously elevated blood ethanol levels and alcohol withdrawal syndrome in hamsters during periods of comparatively high daily ethanol intake.
如先前报道，仓鼠比大鼠表现出更高的乙醇摄入量和偏好。然而，随着乙醇逐渐添加到甜味溶液中，仓鼠的乙醇摄入量在较长时间内并未持续超过乙醇代谢能力。在从未接触过乙醇的仓鼠和大鼠中，体外分离肝细胞的乙醇脱氢酶活性和乙醇代谢率以及体内血液乙醇消除率显示出一致的种间差异，这与物种在乙醇摄入量和偏好上的差异相对应。这些数据表明乙醇代谢在调节啮齿动物最大自由选择乙醇摄入量方面具有限制作用，并解释了在仓鼠每日乙醇摄入量相对较高的时期内，其血液乙醇水平为何没有持续升高以及为何没有出现酒精戒断综合征。
