Turner J W
Physiol Behav. 1979 Nov;23(5):845-9. doi: 10.1016/0031-9384(79)90188-4.
Utilizing subcutaneous silastic implants containing testosterone the effect of sustained low-level release of testosterone on marking behavior in castrated Mongolian gerbils was determined. Castration resulted in a decrease in marking frequency from 38 +/- 4 to 4 +/- 1. Sustained release of 6 micrograms testosterone per day from implants did not stimulate marking behavior. Daily release of 11 micrograms increased marking 550% after one week. Release of 17 micrograms per day was required to restore marking to intact levels. Similar release rates of cholesterol did not increase marking. Release rates which increased marking in males did not increase marking in females. The minimum effective sustained-release dose of testosterone necessary to stimulate marking in females was five times greater than that in males. This difference is not due to a sex difference in plasma testosterone removal rates, since the circulating half-life of 3H-testosterone measured by testosterone-specific radioassay was not different in castrated males (72 +/- 5 min) and females (66 +/- 4 min). The present data are consistent with the hypothesis that there is a sexual dimorphism in the testosterone responsiveness of the neural substrate regulating territorial marking behavior.
利用含有睾酮的皮下硅橡胶植入物，确定了睾酮持续低水平释放对去势蒙古沙鼠标记行为的影响。去势导致标记频率从38±4降至4±1。植入物每天持续释放6微克睾酮并未刺激标记行为。每天释放11微克在一周后使标记增加了550%。每天需要释放17微克才能将标记恢复到完整水平。类似的胆固醇释放速率并未增加标记。在雄性中增加标记的释放速率在雌性中并未增加标记。刺激雌性标记所需的睾酮最低有效持续释放剂量是雄性的五倍。这种差异并非由于血浆睾酮清除率的性别差异，因为通过睾酮特异性放射测定法测量的3H-睾酮在去势雄性（72±5分钟）和雌性（66±4分钟）中的循环半衰期并无差异。目前的数据与以下假设一致，即调节领地标记行为的神经底物对睾酮的反应存在性别二态性。
