一些新型硫代氨基脲的单胺氧化酶和丙酮酸氧化酶抑制特性及其抗惊厥活性。
Monoamine oxidase and pyruvate oxidase inhibitory properties of some newer thiosemicarbazones and their anticonvulsant activity.
作者信息
Agrawal D K, Pandey B R
出版信息
Res Commun Chem Pathol Pharmacol. 1979 Dec;26(3):525-33.
PMID:523787
Abstract
Seventeen 4-[3-(N-cyclohexylamino)propyl]-1-substituted-3-thiosemicarbazones were synthesized and evaluated for their ability to inhibit rat brain monoamine oxidase (MAO) and pyruvate oxidase in vitro. Anticonvulsant activity exhibited by these thiosemicarbazones (100 mg/kg,i.p.) against pentylenetetrazol-induced seizures ranged from 10-50%.
摘要
合成了17种4-[3-(N-环己基氨基)丙基]-1-取代-3-硫代氨基脲，并对其体外抑制大鼠脑单胺氧化酶(MAO)和丙酮酸氧化酶的能力进行了评估。这些硫代氨基脲(100mg/kg，腹腔注射)对戊四氮诱导的惊厥的抗惊厥活性范围为10%-50%。
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