一些新型吲哚基咪唑啉酮的单胺氧化酶抑制和抗惊厥特性
Monoamine oxidase inhibitory and anticonvulsant properties of some newer indolylimidazolones.
作者信息
Mehrotra S, Dhasmana A, Gupta T K, Parmar S S, Barthwal J P
出版信息
Res Commun Chem Pathol Pharmacol. 1987 Jun;56(3):421-4.
PMID:3628969
Abstract
Newly synthesized indolylimidazolones were tested for their in vitro monoamine oxidase (MAO) inhibitory activity. These compounds were found to possess analgesic activity and anticonvulsant activity against maximal electroshock-induced convulsions in mice. The low toxicity of these compounds was reflected by their high approximate LD50 values.
摘要
对新合成的吲哚基咪唑啉酮进行了体外单胺氧化酶（MAO）抑制活性测试。发现这些化合物具有镇痛活性，并且对小鼠最大电休克诱导的惊厥具有抗惊厥活性。这些化合物的低毒性体现在其较高的近似半数致死量（LD50）值上。
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