抗惊厥吡唑啉对大鼠脑单胺氧化酶和琥珀酸脱氢酶的抑制作用。
Inhibition of rat brain monoamine oxidase and succinic dehydrogenase by anticonvulsant pyrazolines.
作者信息
Soni N, Pande K, Kalsi R, Gupta T K, Parmar S S, Barthwal J P
出版信息
Res Commun Chem Pathol Pharmacol. 1987 Apr;56(1):129-32.
PMID:3589148
Abstract
Substituted 1,5-diaryl-3(4-chlorophenyl)-delta 2-pyrazolines were synthesized and evaluated for anticonvulsant activity. Most pyrazolines (100 mg/kg) provided 20-80% protection against pentylenetetrazol-induced convulsions in mice. All compounds inhibited rat brain mitochondrial monoamine oxidase (MAO) and succinic dehydrogenase (SDH) and exhibited low toxicity as reflected by approximate LD50 values (500 to greater than 1000 mg/kg) in mice.
摘要
合成了取代的1,5 - 二芳基 - 3(4 - 氯苯基)-δ² - 吡唑啉，并对其抗惊厥活性进行了评估。大多数吡唑啉（100毫克/千克）对小鼠戊四氮诱导的惊厥提供了20 - 80%的保护作用。所有化合物均抑制大鼠脑线粒体单胺氧化酶（MAO）和琥珀酸脱氢酶（SDH），并且从小鼠的近似半数致死量值（500至大于1000毫克/千克）可以看出其毒性较低。
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