Jun M H, Johnson R H
Res Vet Sci. 1979 Sep;27(2):155-60.
Cyclophosphamide (CY) is shown to associate with partial or complete regression of ovine squamous cell carcinoma (OSCC), the rate of regression varying directly with CY dosage and inversely with maturity of tumour at the start of therapy. CY treatment given coincidental with injection of tumour extracts (TA) completely neutralised the tumour enhancement effects regularly associated with TA injections, and caused tumour regression comparable to that seen in sheep treated with CY alone. In discussion of the results, which incorporate parallel studies on cell-mediated responses, it is suggested that immunosuppression during tumour growth is due to formation of B suppressor lymphocytes and that CY treatment of OSCC may exert beneficial effects through its immunosuppressive action on such lymphocytes as much as its direct cytotoxic action on tumour cells.
环磷酰胺（CY）已被证明与绵羊鳞状细胞癌（OSCC）的部分或完全消退有关，消退率与CY剂量成正比，与治疗开始时肿瘤的成熟度成反比。与肿瘤提取物（TA）注射同时进行的CY治疗完全中和了通常与TA注射相关的肿瘤增强作用，并导致肿瘤消退，其程度与单独用CY治疗的绵羊所见相当。在讨论这些结果时，其中纳入了对细胞介导反应的平行研究，有人提出肿瘤生长期间的免疫抑制是由于B抑制淋巴细胞的形成，并且OSCC的CY治疗可能通过其对这类淋巴细胞的免疫抑制作用以及对肿瘤细胞的直接细胞毒性作用发挥有益效果。
