Jun M H, Johnson R H
Res Vet Sci. 1979 Sep;27(2):161-6.
Sera from sheep with ovine squamous cell carcinoma are shown to contain a factor which nonspecifically inhibits blastogenesis of T lymphocytes. This blastogenic inhibitor is stable at 56 degrees C for 30 min, passes a 430 nm filter, and increases in concentration (or efficiency) with increasing tumour volume. Tumour removal is associated with effective circulatory disappearance of the inhibitor and coincides with recovery of cell-mediated responses within five weeks. The inhibitor adsorbs readily to leucocyte populations from normal and tumour removed sheep. It is suggested that the blastogenic inhibitor is mediated by the tumour to cause immunosuppression through an undetermined B lymphocyte suppressor pathway, and acts as a mechanism protecting the tumour from immune rejection by T lymphocytes.
患有绵羊鳞状细胞癌的绵羊血清显示含有一种能非特异性抑制T淋巴细胞增殖的因子。这种增殖抑制因子在56摄氏度下30分钟内稳定，能通过430纳米的滤膜，且其浓度（或效力）随肿瘤体积的增大而增加。肿瘤切除与抑制剂在循环系统中的有效消失相关，且与五周内细胞介导反应的恢复同时发生。该抑制剂很容易吸附到正常绵羊和切除肿瘤的绵羊的白细胞群体上。有人提出，增殖抑制因子由肿瘤介导，通过一条未明确的B淋巴细胞抑制途径引起免疫抑制，并作为一种机制保护肿瘤免受T淋巴细胞的免疫排斥。
