绵羊鳞状细胞癌免疫治疗后的增强与转移

Jun M H, Johnson R H, Maguire D J, Hopkins P S

Br J Cancer. 1978 Sep;38(3):382-91. doi: 10.1038/bjc.1978.218.

Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development. Extracts of foetal sheep skin at the 3mg-protein level produced significant enhancement and metastasis. The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment.

通过不同程序制备的绵羊鳞状细胞癌（OSCC）提取物，以不同浓度注射到184只荷瘤绵羊体内。当总蛋白含量为0.5毫克及以上时，在所有检查的120只绵羊中均出现了显著的肿瘤生长加速和转移。蛋白含量低于0.5毫克的OSCC提取物，或蛋白含量高的人鳞状细胞癌和正常绵羊皮肤提取物，对后续肿瘤发展没有影响。3毫克蛋白水平的胎羊皮肤提取物产生了显著的肿瘤生长加速和转移。加速程度与治疗时肿瘤的发育阶段成反比。