Pedersen G, Pedersen A, Pedersen E B
Scand J Clin Lab Invest. 1979 Apr;39(2):167-70. doi: 10.3109/00365517909106089.
Total exchangeable body potassium (KE) was determined in fifteen patients with essential hypertension, and total exchangeable body sodium (NaE) in ten, before and after propranolol administration for 2-3 months. Blood pressure was reduced; serum potassium increased, but KE was unchanged. Serum sodium and NaE were unaffected during therapy. It is concluded that the increase in serum potassium during propranolol treatment could not be attributed to potassium retention, but is possibly due to a displacement from the intra- to the extracellular fluid compartment. The antihypertensive effect of propranolol could not be related to changes in NaE.
在15例原发性高血压患者中测定了可交换体钾总量（KE），并在10例患者中测定了可交换体钠总量（NaE），这些测定在普萘洛尔给药2 - 3个月前后进行。血压降低；血清钾升高，但KE未变。治疗期间血清钠和NaE未受影响。结论是，普萘洛尔治疗期间血清钾的升高不能归因于钾潴留，而可能是由于钾从细胞内液向细胞外液的转移。普萘洛尔的降压作用与NaE的变化无关。
