Alakeel Abduallah, Alsalman Hanan, Alotaibi Ghadah, Somily Haneen, Alsohime Fahad
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Family Med Prim Care. 2022 Nov;11(11):6944-6948. doi: 10.4103/jfmpc.jfmpc_658_22. Epub 2022 Dec 16.
Infantile hemangioma is the most frequent benign vascular tumor of infancy, which has a specific clinical history of early growth, followed by spontaneous remission. Since the fortuitous discovery of propranolol's efficacy in 2008, the management of infantile hemangioma has been quickly developing.
This study is a retrospective cohort study. Electronic search in the patient's registry of King Khalid University Hospital, Riyadh, Saudi Arabia, was performed using the keywords hemangioma, haemangioma, infantile hemangioma, and vascular tumors. The search revealed a total of 101 subjects for which 56 were included and 45 were excluded.
A total of 56 patients with infantile hemangioma were evaluated in this study. The majority were females. The F: M ratio is 3.4:1. The highest percentage of the patients was delivered by the elective cesarian section, that is, 23 (41.1%), followed by spontaneous vaginal delivery, that is, 19 (33.9%). Full-term patients were 27 (48%), whereas the pre-term patients were 21 (37%). The total number of patients who developed hyperkalemia while on propranolol was 12 (31%). There was no statistically significant difference (P > 0.05) between patients who developed hyperkalemia and patients who did not develop hyperkalemia in terms of gender, gestational age, mode of delivery, size and location of hemangioma, or concomitant topical timolol use.
Hyperkalemia is benign and transient, although solid conclusive opinions cannot be drawn because of the small sample size and the retrospective nature of the study.
婴儿血管瘤是婴儿期最常见的良性血管肿瘤，具有早期生长、随后自发消退的特定临床病程。自2008年偶然发现普萘洛尔的疗效以来，婴儿血管瘤的治疗迅速发展。
本研究为回顾性队列研究。使用关键词血管瘤、婴儿血管瘤和血管肿瘤，在沙特阿拉伯利雅得哈立德国王大学医院的患者登记处进行电子检索。检索共发现101名受试者，其中56名被纳入，45名被排除。
本研究共评估了56例婴儿血管瘤患者。大多数为女性。男女比例为3.4:1。患者中择期剖宫产分娩的比例最高，即23例（41.1%），其次是自然阴道分娩，即19例（33.9%）。足月患者为27例（48%），而早产患者为21例（37%）。服用普萘洛尔期间发生高钾血症的患者总数为12例（31%）。在发生高钾血症的患者与未发生高钾血症的患者之间，在性别、胎龄、分娩方式、血管瘤大小和位置或是否同时使用局部噻吗洛尔方面，差异无统计学意义（P>0.05）。
高钾血症是良性且短暂的，尽管由于样本量小和研究的回顾性性质，无法得出确凿的结论性意见。
