Magura C E, Spector M
Scan Electron Microsc. 1979(3):713-20.
Ultrastructural studies of human prostatic corpora amylacea and corpora calculi, and prostatic calculi were conducted in order to delineate their etiology and pathogenesis. Scanning electron microscopy was employed in conjunction with histology and transmission electron microscopy in the study of prostatic tissues and concretions obtained from 21 individuals. Results confirmed that desquamated acinar cells contribute to the formation and growth of corpora amylacea. A variation in density of the matrix of the matrix of the corpora produces a laminated structure. The deposition of hydroxyapatite crystallites in corpora amylacea leads to the formation of corpora calculi. Further growth and mineralization of corpora calculi lead to the development of the more clinically significant prostatic calculi. Small spherical aggregates (from 0.5 to 5 micron in diameter) of hydroxyapatite crystallites are a prevalent constituent of the corpora and prostatic calculi. Similar spherical aggregates of hydroxyapatite crystallites have also been identified in urinary calculi and other pathologic tissues suggesting similar mechanisms of mineral precipitation.
为了阐明人前列腺淀粉样体、前列腺结石和前列腺钙化的病因及发病机制，对其进行了超微结构研究。在对21例个体的前列腺组织和结石进行研究时，采用了扫描电子显微镜，并结合组织学和透射电子显微镜。结果证实，脱落的腺泡细胞有助于淀粉样体的形成和生长。淀粉样体基质密度的变化产生了层状结构。淀粉样体中羟基磷灰石微晶的沉积导致了前列腺结石的形成。前列腺结石的进一步生长和矿化导致了临床上更具意义的前列腺钙化的发展。羟基磷灰石微晶的小球形聚集体（直径0.5至5微米）是前列腺体和前列腺结石的普遍成分。在尿路结石和其他病理组织中也发现了类似的羟基磷灰石微晶球形聚集体，提示矿物质沉淀的机制相似。
