Brock D J
Clin Genet. 1975 Oct;8(4):297-301. doi: 10.1111/j.1399-0004.1975.tb01505.x.
Alpha2-macroglobulin (AMG) concentrations have been measured in amniotic fluids from 33 pregnancies where the outcome was an infant with a neural tube defect. AMG ranged from 1.3 to 50 mug/ml in these samples, but was undetectable (is less than 1 mug/ml) in matched controls. Since the abnormal samples included four cases of spina bifida and eight cases of anencephaly before 22 weeks of pregnancy, measurement of AMG concentrations may be useful in the early antenatal diagnosis of neural tube defects. In some cases it gave clearer results than those obtained by measurement of amniotic fluid alphafetoprotein. However, care must be excercised to ensure that amniotic fluids are not contaminated by blood.
已对33例妊娠结局为神经管缺陷婴儿的羊水样本进行了α2-巨球蛋白（AMG）浓度测定。这些样本中的AMG浓度范围为1.3至50微克/毫升，但在匹配的对照样本中未检测到（低于1微克/毫升）。由于异常样本包括4例脊柱裂和8例妊娠22周前的无脑儿，因此测定AMG浓度可能有助于神经管缺陷的早期产前诊断。在某些情况下，其结果比通过测定羊水甲胎蛋白得到的结果更清晰。然而，必须注意确保羊水不被血液污染。
