Ishihara Y, Kitamura S
Tohoku J Exp Med. 1979 Nov;129(3):303-9. doi: 10.1620/tjem.129.303.
The effects of tartrazine on the synthesis of prostaglandin-like substances (PGLS) from arachidonic acid in isolated perfused guinea pig lung, and on the contractile responses of guinea pig tracheal tissues induced by histamine, acetylcholine, bradykinin, serotonin and prostaglandin F2 alpha were studied. The synthesis of PGLS from arachidonic acid was not inhibited by tartrazine. The contractile responses of guinea pig tracheal tissues induced by various bronchoconstrictors were potentiated in the presence of tartrazine. These results may suggest that tartrazine-induced asthma is not induced by inhibition of PGLS synthesis, but induced by potentiation of bronchoconstrictor responses.
研究了酒石黄对离体灌注豚鼠肺中花生四烯酸合成类前列腺素物质（PGLS）的影响，以及对组胺、乙酰胆碱、缓激肽、5-羟色胺和前列腺素F2α诱导的豚鼠气管组织收缩反应的影响。酒石黄未抑制花生四烯酸合成PGLS。在酒石黄存在的情况下，各种支气管收缩剂诱导的豚鼠气管组织收缩反应增强。这些结果可能表明，酒石黄诱发的哮喘不是由抑制PGLS合成引起的，而是由支气管收缩反应增强引起的。
