Gerber J G, Payne N A, Oelz O, Nies A S, Oates J A
J Allergy Clin Immunol. 1979 Apr;63(4):289-94. doi: 10.1016/0091-6749(79)90115-5.
The effect of tartrazine on prostaglandin production was evaluated in several in vitro systems in order to elucidate the interrelationship between aspirin-sensitive asthma and tartrazine. Unlike the nonsteroidal anti-inflammatory drugs, tartrazine did not inhibit cyclooxygenase activity in sheep seminal vesicles, guinea pig lung microsomes, and human platelets. Tartrazine had no effect on the activation of acyl hydrolase, which is the rate-limiting step in prostaglandin production. The major metabolite of tartrazine, sulfanilic acid, also had no inhibitory effect on the sheep seminal vesicle cyclooxygenase. In view of these findings, if there is a cross-sensitivity between tartrazine and aspirin in aspirin-sensitive asthmatics, it is unlikely to be on the basis of prostaglandin inhibition.
为了阐明阿司匹林敏感性哮喘与酒石黄之间的相互关系，在多个体外系统中评估了酒石黄对前列腺素生成的影响。与非甾体抗炎药不同，酒石黄在绵羊精囊、豚鼠肺微粒体和人血小板中并不抑制环氧化酶活性。酒石黄对酰基水解酶的激活没有影响，而酰基水解酶的激活是前列腺素生成中的限速步骤。酒石黄的主要代谢产物对氨基苯磺酸对绵羊精囊环氧化酶也没有抑制作用。鉴于这些发现，在阿司匹林敏感性哮喘患者中，如果酒石黄与阿司匹林之间存在交叉敏感性，不太可能是基于对前列腺素的抑制作用。
