酒石黄与前列腺素系统

Tartrazine and prostaglandin-system.

作者信息

Ceserani R, Colombo M, Robuschi M, Bianco S

出版信息

Prostaglandins Med. 1978 Dec;1(6):499-505. doi: 10.1016/0161-4630(78)90120-9.

Abstract

Tartrazine, a dye largely employed for colouring foods, drinks, drugs and cosmetics, induces in some aspirin-sensitive subjects a bronchoconstriction similar to that caused by aspirin and other nonsteroidal anti-inflammatory drugs. The interference of tartrazine on prostaglandin system of guinea pig lungs perfused with arachidonic acid has been studied. This compound is able to inhibit in the same manner the formation both of prostaglandins and of thromboxane A2 acting at the cyclooxygenase level as has already been demonstrated for aspirin and indomethacin. Preliminary experiments on aspirin asthmatic patients treated or not with tartrazine are discussed.

摘要

酒石黄是一种主要用于食品、饮料、药品和化妆品染色的染料，在一些对阿司匹林敏感的受试者中会诱发类似于阿司匹林和其他非甾体抗炎药所引起的支气管收缩。研究了酒石黄对用花生四烯酸灌注的豚鼠肺前列腺素系统的干扰。这种化合物能够以与阿司匹林和吲哚美辛相同的方式抑制前列腺素和血栓素A2的形成，其作用于环氧化酶水平，这一点已得到证实。讨论了对用或未用酒石黄治疗的阿司匹林哮喘患者的初步实验。