Bigler E D
Electroencephalogr Clin Neurophysiol. 1975 Nov;39(5):491-7. doi: 10.1016/0013-4694(75)90050-4.
Following parenteral administration of subconvulsive levels of pentylenetetrazol (Metrazol) photic stimulation induced an augmented rhythmic sequence of late neuron population burst-inhibition periods in the dorsal lateral geniculate nucleus (LGN) of the rat. This late bursting-inhibition activity was in turn observed to be associated with the augmentation of cortically recorded photically evoked after-discharges (PhADs). Multiple-unit activity (MUA) was also recorded from superior colliculus (SC), reticular formation (RF), posterior thalamic area (PTN), and dorsal hippocampus (HIPP). Only SC and RF exhibited an initial discharge to photic stimulation with late bursting infrequently observed and only in the SC. PTN showed some tonic increases in MUA following photic stimulation. HIPP MUA was essentially unaffected by photic pulse stimulation. The results document the neuronal role of the LGN in PhAD activity and were discussed in terms of a recurrent LGN inhibitory system governing cortical PhAD production and elaboration.
经肠胃外给予亚惊厥剂量的戊四氮（卡地阿唑）后，光刺激诱发大鼠背侧外侧膝状核（LGN）中晚期神经元群体爆发抑制期的节律性序列增强。反过来，观察到这种晚期爆发抑制活动与皮层记录的光诱发后放电（PhADs）增强有关。还记录了上丘（SC）、网状结构（RF）、丘脑后区（PTN）和背侧海马体（HIPP）的多单位活动（MUA）。只有SC和RF对光刺激表现出初始放电，很少观察到晚期爆发，且仅在SC中观察到。PTN在光刺激后MUA有一些紧张性增加。HIPP的MUA基本上不受光脉冲刺激的影响。结果证明了LGN在PhAD活动中的神经元作用，并根据控制皮层PhAD产生和细化的LGN反复抑制系统进行了讨论。
