Bigler E D
Electroencephalogr Clin Neurophysiol. 1976 Oct;41(4):428-33. doi: 10.1016/0013-4694(76)90107-3.
The effects of diazepam on evoked and spontaneous activity of dorsal lateral geniculate nucleus (dLGN) principal (P) and inhibtory (I) cells were examined in rats. In the majority of P cells tested both spontaneous and evoked activity were suppressed following diazepam treatment with these effects being altered little by a pentylenetetrazol (Metrazol) challenge. In two P cells, which were offresponding to photic pulse stimulation, evoked and spontaneous activity was enhanced by diazepam but again these effects were altered little by the Metrazol challenge. I cell spontaneous activity was suppressed by diazepam and augmented by the Metrazol challenge; however, post-stimulus activity was relatively unaffected by either treatment. These results were discussed in terms of support for a functional re-evaluation of the rat dLGN.
在大鼠中研究了地西泮对背外侧膝状核（dLGN）主细胞（P细胞）和抑制性细胞（I细胞）的诱发活动及自发活动的影响。在大多数接受测试的P细胞中，地西泮处理后自发活动和诱发活动均受到抑制，用戊四氮（卡地阿唑）激发后这些效应变化不大。在两个对光脉冲刺激呈非反应性的P细胞中，地西泮增强了诱发活动和自发活动，但同样，用卡地阿唑激发后这些效应变化不大。I细胞的自发活动被地西泮抑制，而被卡地阿唑激发增强；然而，刺激后的活动相对不受任何一种处理的影响。根据对大鼠dLGN功能重新评估的支持对这些结果进行了讨论。
