采用离子交换树脂血液灌流法清除胆红素。

Removal of bilirubin by hemoperfusion with ion exchange resins.

作者信息

Sideman S, Mor L, Brandes J M

出版信息

Trans Am Soc Artif Intern Organs. 1979;25:497-501.

Abstract

Removal of bilirubin by hemoperfusion with macroporous resins is suggested to replace exchange transfusion of blood from jaundiced infants. Anion exchangers tested for BIL binding rate and the effects of various system parameters, i.e. particle size, temperature, bed volume, fluid flow rate and particle porosity are reported. The dissociation equilibrium constant K of the BIL-ALB (albumin) complex was determined from the equilibrium adsorption isotherms data, at different ALB concentrations. Increasing ALB concentration decreased the BIL adsorption rate. For a given ALB concentration, the ratio of unbound to total BIL was constant and the initial BIL adsorption rate was independent of total BIL concentration.

摘要

有人建议用大孔树脂血液灌流法去除胆红素，以替代黄疸婴儿的换血疗法。本文报道了对阴离子交换剂进行胆红素结合率测试以及各种系统参数（即粒径、温度、床体积、流体流速和颗粒孔隙率）影响的研究结果。根据不同白蛋白（ALB）浓度下的平衡吸附等温线数据，测定了胆红素-白蛋白（ALB）复合物的解离平衡常数K。白蛋白浓度增加会降低胆红素的吸附率。在给定的白蛋白浓度下，未结合胆红素与总胆红素的比值是恒定的，且初始胆红素吸附率与总胆红素浓度无关。