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Irrevesible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal sulfonyl fluoride.

作者信息

Baker B R, Meyer R B

出版信息

J Med Chem. 1969 Mar;12(2):224-7. doi: 10.1021/jm00302a007.

DOI:10.1021/jm00302a007
PMID:5254099
Abstract
摘要

相似文献

1
Irrevesible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal sulfonyl fluoride.不可逆酶抑制剂。CLI。源自5-（对氨基苯基丁基）-2,4-二氨基嘧啶并带有末端磺酰氟的二氢叶酸还原酶的活性位点定向不可逆抑制剂。
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Irreversible enzyme inhibitors. CXIX. Active-site-directed irreversible inhibitors of dihydrofolic reductase with tissue specificity derived from 2,4,6-triaminopyrimidine with a terminal sulfonyl fluoride at the 5 position.不可逆酶抑制剂。CXIX。具有组织特异性的二氢叶酸还原酶活性位点导向不可逆抑制剂，其衍生自5位带有末端磺酰氟的2,4,6 - 三氨基嘧啶。
J Med Chem. 1968 May;11(3):489-94. doi: 10.1021/jm00309a018.
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Irreversible enzyme inhibitors. 138. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenethyl)-- 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with a terminal sulfonyl fluoride.
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Irreversible enzyme inhibitors. 143. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenoxypropyl)-2,4-diamino-6-methylpyrimidine with a terminal sulfonyl fluoride.
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Irreversible enzyme inhibitors. CXLII. Further studies on active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-Aminophenoxypropyl)-2,4,6-triaminopyrimidine bearing a terminal sulfonyl fluoride.
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Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride.
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Irreversible enzyme inhibitors. 108. 6-(p-chloroacetylanilinomethyl)-5-(p-chlorophenyl)-2,4-diaminopyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase.不可逆酶抑制剂。108. 6-（对氯乙酰苯胺甲基）-5-（对氯苯基）-2,4-二氨基嘧啶，一种二氢叶酸还原酶的活性位点导向不可逆抑制剂。
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Irreversible enzyme inhibitors. CXX. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-substituted 2,4-diamino-5-phenylpyrimidines with tissue specificity.
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Irreversible enzyme inhibitors. 178. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with a terminal sulfonyl fluoride.不可逆酶抑制剂。178. 源自1-(4-苄氧基-3-氯苯基)-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪并带有末端磺酰氟的二氢叶酸还原酶的活性位点导向不可逆抑制剂。
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Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.不可逆酶抑制剂。CXXXVI。2,4-二氨基-5-(3,4-二氯苯基)-6-[对-(间-氟磺酰基苯甲酰胺基)苯氧基甲基]嘧啶，一种二氢叶酸还原酶的活性位点导向不可逆抑制剂。结构对同工酶特异性的影响。
J Med Chem. 1969 Jan;12(1):82-5.