吸入的2-甲基呋喃和2,5-二甲基呋喃的潴留

Retention of inhaled 2-methylfuran and 2,5-dimethylfuran.

作者信息

Egle J L, Gochberg B J

出版信息

Am Ind Hyg Assoc J. 1979 Oct;40(10):866-9. doi: 10.1080/15298667991430415.

Abstract

The respiratory tract retention of 2-methylfuran and 2,5-dimethylfuran in the dog have been studied as part of a broad investigation of substances found in the vapor phase of cigarette smoke. Retention of 2-methylfuran tended to be higher that that of 2,5-dimethylfuran in the upper, lower and total respiratory tract. Uptake of 2-methylfuran ranged from 63-88% in these regions while it was only 53-62% for 2,5-dimethylfuran. Retention of 2,5-dimethylfuran was lower than any of the other compounds studied. However, the majority of either compound will be absorbed by the respiratory tract when inhalation occurs.

摘要

作为对香烟烟雾气相中发现的物质进行广泛研究的一部分，对狗呼吸道中2-甲基呋喃和2,5-二甲基呋喃的滞留情况进行了研究。在上呼吸道、下呼吸道和整个呼吸道中，2-甲基呋喃的滞留率往往高于2,5-二甲基呋喃。在这些区域，2-甲基呋喃的摄取率为63%-88%，而2,5-二甲基呋喃仅为53%-62%。2,5-二甲基呋喃的滞留率低于所研究的任何其他化合物。然而，当发生吸入时，这两种化合物中的大多数都会被呼吸道吸收。