大鼠脑细胞核巨大多聚腺苷酸RNA与微粒体多聚腺苷酸RNA之间的关系。
Relationship between nuclear giant-size dRNA and microsomal dRNA of rat brain.
作者信息
Stévenin J, Mandel P, Jacob M
出版信息
Proc Natl Acad Sci U S A. 1969 Feb;62(2):490-7. doi: 10.1073/pnas.62.2.490.
Abstract
(1) Among the DNA-like RNA (dRNA) species of rat brain, 35 per cent remain nuclear, whereas 65 per cent are found in the microsomes and may represent functional messenger RNA. It was estimated that 30,000-300,000 cistrons would thus code for messenger RNA in rat brain.(2) No nuclear-specific dRNA with sedimentation characteristics similar to microsomal dRNA are detected.(3) The nuclear large dRNA contain all the dRNA species of the brain.(4) The presence of microsomal dRNA precursors and of nuclear restricted dRNA in large dRNA suggests the existence of a limited cleavage process and of a selection among the fragments for their transport from the nucleus to the cytoplasm. Such a selective mechanism could represent an important regulation step in the transfer of genetic information.
摘要
(1) 在大鼠脑的类DNA核糖核酸（dRNA）种类中，35%保留在细胞核内，而65%存在于微粒体中，可能代表功能性信使核糖核酸。据估计，大鼠脑中30,000 - 300,000个顺反子会编码信使核糖核酸。(2) 未检测到具有与微粒体dRNA相似沉降特性的核特异性dRNA。(3) 核大dRNA包含脑中所有的dRNA种类。(4) 大dRNA中存在微粒体dRNA前体和核限制性dRNA，这表明存在有限的切割过程以及在片段中进行选择以便从细胞核转运到细胞质。这种选择性机制可能代表遗传信息传递中的一个重要调控步骤。
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