Fritzsch B
Anat Embryol (Berl). 1979;158(1):95-102. doi: 10.1007/BF00315954.
The cerebellar noduli of 18 neonatal mice and 13 young chickens were studied by light and electron microscopy. Beginning with postnatal day 10 in mice and incubation day 17 in chickens some Purkinje cells of the nodulus show degenerative changes. The nuclei and cytoplasm of these cells are darker than the neighbouring tissue due to an accumulation of large amounts of ribosomelike particles and an increased stainability of the cytoplasm. Mitochondria and endoplasmic reticulum undergo a moderate swelling, the Golgi apparatus hypertrophies whereas the somata and nuclei atrophy. The percentage of degenerating Purkinje cells reaches a peak of about 45% around postnatal day 14 in mice and the 4th day after hatching in chickens. In 26 otocyst-deprived chickens a smaller proportion of Purkinje cells with degenerative changes is found. The way in which the otocyst removal influences the neonatal Purkinje cell degeneration is not clear.
通过光学显微镜和电子显微镜对18只新生小鼠和13只幼鸡的小脑小结进行了研究。从小鼠出生后第10天和鸡孵化后第17天开始，小结中的一些浦肯野细胞出现退行性变化。由于大量核糖体样颗粒的积累和细胞质染色性的增加，这些细胞的细胞核和细胞质比邻近组织颜色更深。线粒体和内质网出现中度肿胀，高尔基体肥大，而胞体和细胞核萎缩。在小鼠出生后第14天左右和鸡孵化后第4天，退化的浦肯野细胞百分比达到约45%的峰值。在26只去除耳囊的鸡中，发现有退行性变化的浦肯野细胞比例较小。耳囊切除影响新生浦肯野细胞退化的方式尚不清楚。
