莱茵衣藻叶绿体的遗传功能：利福平对叶绿体DNA依赖性RNA聚合酶的影响。
Genetic functions of the chloroplast of Chlamydomonas reinhardi: effect of rifampin on chloroplast DNA-dependent RNA polymerase.
作者信息
Surzycki S J
出版信息
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1327-34. doi: 10.1073/pnas.63.4.1327.
Abstract
The effect of rifampin, an inhibitor of bacterial DNA-dependent RNA polymerase, was studied in Chlamydomonas reinhardi. It was shown, in vivo and in vitro, that chloroplast-located, but not nuclear, DNA-dependent RNA polymerase is inhibited by this drug. The inhibition of chloroplast RNA polymerase results in the inhibition of chloroplast rRNA synthesis, and thus in the loss of chloroplast ribosomes. The ability to carry out photosynthesis is also lost after prolonged heterotrophic growth in the presence of rifampin, but cell division and chloroplast replication are not affected. It is proposed that chloroplast DNA contains information for chloroplast rRNA, but this DNA does not have the information for chloroplast DNA polymerase. Moreover, the DNA polymerase is not synthesized on chloroplast ribosomes.
摘要
研究了细菌DNA依赖性RNA聚合酶抑制剂利福平对莱茵衣藻的作用。体内和体外实验均表明，该药物可抑制位于叶绿体而非细胞核的DNA依赖性RNA聚合酶。叶绿体RNA聚合酶的抑制导致叶绿体rRNA合成受抑，进而导致叶绿体核糖体丧失。在利福平存在的情况下长期异养生长后，光合作用能力也会丧失，但细胞分裂和叶绿体复制不受影响。有人提出，叶绿体DNA包含叶绿体rRNA的信息，但该DNA不具有叶绿体DNA聚合酶的信息。此外，DNA聚合酶不是在叶绿体核糖体上合成的。
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