宫内生活期间用卡那霉素中毒的豚鼠毛细胞变性；一项结构和超微结构研究。
Hair cell degeneration in guinea pigs intoxicated with kanamycin during intrauterine life; a structural and ultrastructural study.
作者信息
Uziel A, Gabrion J, Romand R
出版信息
Arch Otorhinolaryngol. 1979;224(3-4):187-91. doi: 10.1007/BF01108777.
PMID:526183
Abstract
The structural ototoxic effect of kanamycin during intrauterine life has been shown in guinea pigs. The extent of the loss mostly affected the outer hair cells of the basal part of the cochlea. Ultrastructural studies demonstrated a hair cell degeneration pattern similar to that previously described in adult animals following antibiotic intoxication.
摘要
卡那霉素在子宫内生活期间对豚鼠的结构耳毒性作用已得到证实。损失程度主要影响耳蜗基部的外毛细胞。超微结构研究显示，毛细胞退化模式与先前描述的成年动物抗生素中毒后的模式相似。
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