Oats J N, Vasey D P, Waldron B A
Br J Anaesth. 1979 Dec;51(12):1163-6. doi: 10.1093/bja/51.12.1163.
Intra-uterine pressure was recorded by placing a Foley catheter in the extra-amniotic space before the termination of pregnancy in 25 patients, and Caesarean section in 12 patients. The effects of administration of i.v. ketamine 2 mg/kg body weight, sodium thiopentone 4 mg/kg body weight and ergometrine 0.5 mg, and intra-cervical 0.5% lignocaine 20 ml were measured in the first trimester of pregnancy, and i.v. ketamine and sodium thiopentone in late pregnancy. Ketamine was found to cause uterine contraction (mean increase 16.1 mm Hg) equal to ergometrine (mean increase 14.8 mm Hg) in early pregnancy, but exert no effect (mean decrease -- 1.33 mm Hg) in late pregnancy. Lignocaine in early pregnancy given as a paracervical block had no significant effect on intrauterine pressure (mean increase 0.33 mm Hg). Sodium thiopentone (mean decrease -- 4.28 mm Hg first trimester and -- 2.22 mm Hg at term) in late pregnancy had no significant effect on intra-uterine pressure.
在25例患者终止妊娠前，通过在羊膜外间隙放置Foley导管记录子宫内压力，其中12例行剖宫产。在妊娠早期，测量静脉注射2mg/kg体重氯胺酮、4mg/kg体重硫喷妥钠和0.5mg麦角新碱以及宫颈内注射20ml 0.5%利多卡因的效果；在妊娠晚期，测量静脉注射氯胺酮和硫喷妥钠的效果。结果发现，氯胺酮在妊娠早期可引起子宫收缩（平均升高16.1mmHg），与麦角新碱（平均升高14.8mmHg）相当，但在妊娠晚期无作用（平均降低-1.33mmHg）。妊娠早期宫颈旁阻滞给予的利多卡因对子宫内压力无显著影响（平均升高0.33mmHg）。硫喷妥钠在妊娠晚期（妊娠早期平均降低-4.28mmHg，足月时平均降低-2.22mmHg）对子宫内压力无显著影响。
