拉贝洛尔对动态血压的影响。
Effect of labetalol on continuous ambulatory blood pressure.
作者信息
Balasubramanian V, Mann S, Raftery E B, Millar-Craig M W, Altman D
出版信息
Br J Clin Pharmacol. 1979;8(Suppl 2):119S-123S.
Abstract
1 The hypotensive action of labetalol was evaluated during 24 h by continuous intra-arterial ambulatory monitoring in 14 patients. The dose used ranged from 300--1800 mg daily. 2 The drug caused a significant reduction of systolic BP in 19 and diastolic BP in 20 of the 24 h of monitoring. Heart rate was also reduced but less markedly than BP. 3 The rapid early morning increase in BP was also effectively controlled. 4 The mild pre-waking increase in BP was not significantly reduced. 5 Labetalol treatment reduced the variation in systolic BP from the lowest observed quarter-hourly mean as compared with pre-treatment values. 6 The quarter hourly mean values were consistently smooth and revealed no sudden variations which might have resulted from postural hypotension.
摘要
通过对14例患者进行24小时动脉内动态监测，评估了拉贝洛尔的降压作用。所用剂量范围为每日300 - 1800毫克。
在24小时监测期间，该药物使收缩压在19小时、舒张压在20小时显著降低。心率也有所降低，但不如血压明显。
清晨血压的快速上升也得到了有效控制。
清醒前血压的轻度上升没有显著降低。
与治疗前值相比，拉贝洛尔治疗降低了收缩压从观察到的最低每15分钟平均值的变化。
每15分钟的平均值始终平稳，未显示出可能由体位性低血压导致的突然变化。
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Direct arterial pressure recording in unrestricted man.在无拘束的人体中进行直接动脉压记录。
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Circumstances attending 100 sudden deaths from coronary artery disease with coroner's necropsies.伴有验尸官尸检的100例冠状动脉疾病猝死病例的相关情况。
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Circadian variation of blood-pressure.血压的昼夜变化
Lancet. 1978 Apr 15;1(8068):795-7. doi: 10.1016/s0140-6736(78)92998-7.
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Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension.
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Blood pressure and heart rate and withdrawal of antihypertensive drugs.血压、心率与抗高血压药物的撤药
Br Med J. 1977 May 14;1(6071):1243-6. doi: 10.1136/bmj.1.6071.1243.
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