关于哺乳动物染色体中DNA的大小。结构亚基。
On the size of the DNA in the mammalian chromosome. Structural subunits.
作者信息
Lett J T, Klucis E S, Sun C
出版信息
Biophys J. 1970 Mar;10(3):277-92. doi: 10.1016/S0006-3495(70)86300-7.
Abstract
Alkaline degradation of mammalian DNA indicates that the molecule exists in the chromosome as an array of structural subunits. The size of the subunit of single-stranded DNA is circa 5 x 10(8) daltons, and it is of sufficient length to contain a number of synthetic units, replicons. The upper size limit of the multicomponent structure is in excess of 10(10) daltons. Mammalian cells of three different origins have been shown to contain the same basic structural DNA components and these components exist throughout the cell cycle. The nature of the links between the subunits is not known.
摘要
哺乳动物DNA的碱性降解表明，该分子在染色体中以一系列结构亚基的形式存在。单链DNA亚基的大小约为5×10⁸道尔顿，其长度足以包含多个合成单位，即复制子。多组分结构的大小上限超过10¹⁰道尔顿。已证明三种不同来源的哺乳动物细胞含有相同的基本结构DNA成分，并且这些成分在整个细胞周期中都存在。亚基之间连接的性质尚不清楚。
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