左旋咪唑对PHA刺激的人白细胞培养物中干扰素产生的影响。
Effect of levamisole on interferon production by PHA-stimulated human leukocyte cultures.
作者信息
Rhodes-Feuillette A, Canivet M, Andrieu J M, Périès J
出版信息
Biomedicine. 1979 Oct;31(6):170-2.
Mononuclear leukocytes of 10 normal blood donors were cultured in vitro and treated with phytohemagglutinin (PHA-P) and/or levamisole. Interferon-like activity was investigated in the supernatant fluids of the cultures, using VSV as challenge virus. In most of the cases the PHA-stimulated interferon-like activity was slightly but significantly enhanced by levamisole. The antiviral activity produced in the supernatant fluids was characterized as interferon since it was trypsin sensitive, species specific and inhibited by specific antiserum. This interferon has the characteristic sensitivity to PH2 of immune interferon.
对10名正常献血者的单核白细胞进行体外培养，并用植物血凝素（PHA-P）和/或左旋咪唑进行处理。使用水泡性口炎病毒（VSV）作为攻击病毒，研究培养物上清液中的干扰素样活性。在大多数情况下，左旋咪唑可轻微但显著增强PHA刺激的干扰素样活性。上清液中产生的抗病毒活性被鉴定为干扰素，因为它对胰蛋白酶敏感、具有种属特异性且被特异性抗血清抑制。这种干扰素具有免疫干扰素对PH2的特征性敏感性。
Zotero 插件