Differential effect of interferon on the production on virus- and mitogen-induced leukocyte inhibitory factors in human leukocyte cultures.

Interferon treatment of human leukocytes before stimulation with Sendai virus enhanced interferon synthesis but did not affect their leukocyte migration inhibitory factor (LIF) production. The same interferon pretreatment markedly enhanced both LIF and interferon productions when leukocytes were stimulated with concanavalin A.