纳洛酮抑制洛哌丁胺的止泻活性。
Naloxone inhibits the anti-diarrhoeal activity of loperamide.
作者信息
Piercey M F, Ruwart M J
出版信息
Br J Pharmacol. 1979 Jul;66(3):373-5. doi: 10.1111/j.1476-5381.1979.tb10840.x.
Abstract
1 Subcutaneous prostaglandin E2 (2.5 mg/kg) produces profuse diarrhoea in fed rats. 2 Pretreatment of rats with subcutaneous loperamide (1.0 mg/kg) completely prevents prostaglandin-induced diarrhoea. If naloxone is administered prior to loperamide injections the activity of the antidiarrhoeal compound is completely destroyed. 3 These data provide strong evidence that the antidiarrhoeal activity of loperamide is mediated via the opiate receptor.
摘要
- 皮下注射前列腺素E2（2.5毫克/千克）会使喂食的大鼠出现大量腹泻。2. 用皮下注射洛哌丁胺（1.0毫克/千克）对大鼠进行预处理可完全预防前列腺素引起的腹泻。如果在注射洛哌丁胺之前给予纳洛酮，止泻化合物的活性会被完全破坏。3. 这些数据提供了强有力的证据，表明洛哌丁胺的止泻活性是通过阿片受体介导的。
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