洛哌丁胺对大鼠和人体中前列腺素诱导腹泻的影响。
The effect of loperamide on prostaglandin induced diarrhoea in rat and man.
作者信息
Karim S M, Adaikan P G
出版信息
Prostaglandins. 1977 Feb;13(2):321-31. doi: 10.1016/0090-6980(77)90011-9.
PMID:847235
Abstract
Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandins, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.
摘要
洛哌丁胺是一种新型止泻化合物，在成年健康男性志愿者以及接受前列腺素终止妊娠的患者中，它能有效对抗前列腺素诱导的腹泻。该化合物在抑制大鼠小肠中前列腺素诱导的液体蓄积方面有效。洛哌丁胺还能阻断前列腺素、乙酰胆碱和组胺对多种实验动物胃肠道平滑肌制剂的平滑肌刺激作用。
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