Stover B J, Eyring H
Proc Natl Acad Sci U S A. 1970 Jul;66(3):672-6. doi: 10.1073/pnas.66.3.672.
From the steady-state theory of mutation rates we have the probability, q, of the occurrence of a critical change at some site in a cell that leads to genetic alternation, and the probability, p = 1 - q, that the site either is not changed or that it has been repaired. In this paper the formal theory is extended to include survival of biological systems. Single and multiple mechanisms of nonsurvival, and multiple factors acting on a single mechanism, are considered. The number of sites that must be altered to lead to nonsurvival is examined and found to be greater than one. The effect of independent action on separate sets of sites, and the relationship between dose size and survival time are given.
根据突变率的稳态理论，我们有概率q，即在细胞中的某个位点发生导致基因改变的关键变化的概率，以及概率p = 1 - q，即该位点要么未发生改变，要么已被修复。在本文中，形式理论得到了扩展，以包括生物系统的存活情况。考虑了非存活的单一和多种机制，以及作用于单一机制的多种因素。研究了导致非存活必须改变的位点数量，发现其大于一个。给出了对不同位点集的独立作用的影响，以及剂量大小与存活时间之间的关系。
