Stover B J, Eyring H
Proc Natl Acad Sci U S A. 1970 May;66(1):132-9. doi: 10.1073/pnas.66.1.132.
Early in the era of atomic energy the potential of plutonium as an industrial and an environmental hazard was recognized. Thus, the Laboratory for Radiobiology was established at this University 20 years ago to compare the effects of plutonium and radium in beagles. Sufficient data have now accrued for exacting analysis. Concurrently we have formulated the steady-state theory of mutation rates which provides the necessary formalism to assess the survival data from the (239)Pu and (226)Ra study. Although the principal biological end point for both nuclides is the osteosarcoma, the mechanisms of nonsurvival for the two nuclides appear to be different. The success of the theory in this case suggests that application to data on irradiation of more inbred and more outbred species would prove to be exceedingly valuable.
在原子能时代早期，钚作为一种工业和环境危害的潜在性就已被认识到。因此，20年前这所大学设立了放射生物学实验室，以比较钚和镭对小猎犬的影响。现在已经积累了足够的数据用于精确分析。同时，我们已经制定了突变率的稳态理论，该理论提供了必要的形式体系来评估来自钚-239和镭-226研究的存活数据。尽管这两种核素的主要生物学终点都是骨肉瘤，但这两种核素的非存活机制似乎不同。该理论在这种情况下的成功表明，将其应用于更多近交和远交物种的辐照数据将被证明具有极高的价值。
