Olson H M, Shannon C F
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2057-9.
Single doses of Adriamycin (ADR) and isoproterenol in CDF rats produce significant increases in total serum lactate dehydrogenase (LDH) activity, LDH isoenzymes, and LDH-1/LDH-2 ratio. Isoproterenol produced significant increases in LDH-1, LDH-2, and LDH-3 and the LDH-1/LDH-2 ratio; ADR produced significant increases in all isoenzymes, reflecting widespread toxicity, with peak levels of total LDH, LDH isoenzymes, and LDH-1/LDH-2 ratio at 48 hours after injection. While the increased LDH-1/LDH-2 ratio may suggest myocardial leakage with ADR administration, the results are too nonspecific to conclude that the heart is the primary source of serum LDH-1 and LDH-2.
给CDF大鼠单次注射阿霉素（ADR）和异丙肾上腺素后，血清总乳酸脱氢酶（LDH）活性、LDH同工酶以及LDH-1/LDH-2比值显著升高。异丙肾上腺素使LDH-1、LDH-2和LDH-3以及LDH-1/LDH-2比值显著升高；阿霉素使所有同工酶显著升高，反映出广泛的毒性，总LDH、LDH同工酶以及LDH-1/LDH-2比值在注射后48小时达到峰值。虽然LDH-1/LDH-2比值升高可能提示阿霉素给药后心肌渗漏，但结果过于非特异性，无法得出心脏是血清LDH-1和LDH-2的主要来源这一结论。
