Thyagarajan P, Vakil U K, Sreenivasan A
Environ Physiol Biochem. 1975;5(5):283-92.
Exposure to whole-body X-irradiation in rats causes a marked increase in total lactic dehydrogenase (LDH) activity and decrease in H-LDH/M-LDH ratio in serum and tissues, the maximum effect being observed on the 8th post-irradiation day. While there is an elevation of M-LDH isoenzyme, H-LDH remains relatively constant. Studies on incorporation of DL-leucine-l-14C into heart LDH isoenzymes also revealed increased biosynthesis of M-LDH isoenzyme. This indicates that an adaptive mechanism is operative in the X-irradiated rats, whereby, in order to augment anaerobic glycolysis, synthesis of M-LDH is stimulated. Administration of the radioprotector cystamine does not alter the effects of X-irradiation on serum LDH activity.
对大鼠进行全身X射线照射会导致血清和组织中总乳酸脱氢酶（LDH）活性显著增加，H-LDH/M-LDH比值降低，在照射后第8天观察到最大效应。虽然M-LDH同工酶升高，但H-LDH保持相对恒定。对心脏LDH同工酶中DL-亮氨酸-l-14C掺入的研究也表明M-LDH同工酶的生物合成增加。这表明在受X射线照射的大鼠中存在一种适应性机制，即通过刺激M-LDH的合成来增强无氧糖酵解。给予辐射防护剂半胱胺不会改变X射线照射对血清LDH活性的影响。
