大鼠辐射诱导骨肉瘤作为人类骨肉瘤的模型。

Br J Cancer. 1970 Jun;24(2):294-9. doi: 10.1038/bjc.1970.34.

A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the "spontaneous" osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed.

本文描述了一种通过将含（32）P的聚氯乙烯圆盘植入大鼠股骨远端干骺端来局部诱导骨肉瘤的技术。18个月后骨肉瘤的发生率为28%。对大鼠辐射诱导性骨肉瘤与人“自发性”骨肉瘤的病理学进行了比较。并讨论了大鼠骨肉瘤模型的潜在价值。