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1
Low temperature and chloramphenicol induction of respiratory deficiency in a cold-sensitive mutant of Saccharomyces cerevisiae.低温和氯霉素诱导酿酒酵母冷敏感突变体的呼吸缺陷
Proc Natl Acad Sci U S A. 1970 Sep;67(1):52-8. doi: 10.1073/pnas.67.1.52.
2
Induction of respiratory deficiency by repression of the respiratory system in a mutant of Saccharomyces cerevisiae.通过抑制酿酒酵母突变体中的呼吸系统诱导呼吸缺陷
Biochim Biophys Acta. 1968 Feb 12;153(2):341-9. doi: 10.1016/0005-2728(68)90079-0.
3
Control of the mitochondrial genome in Saccharomyces cerevisiae. The fate of mitochondrial membrane proteins and mitochondrial deoxyribonucleic acid during petite induction.酿酒酵母中线粒体基因组的控制。小菌落诱导过程中线粒体膜蛋白和线粒体脱氧核糖核酸的命运。
J Biol Chem. 1971 Aug 25;246(16):5113-9.
4
Effect of D (minus)- and L (plus)-threo-chloramphenicol on nucleotide and related respiratory activities in yeast undergoing metabolic repression and de-repression.D（-）-和L（+）-苏式氯霉素对处于代谢阻遏和去阻遏状态的酵母中核苷酸及相关呼吸活性的影响。
Biochim Biophys Acta. 1970 Feb 18;199(2):476-89. doi: 10.1016/0005-2787(70)90090-0.
5
Induction of the cytoplasmic petite mutation in Saccharomyces cerevisiae by the antibacterial antibiotics erythromycin and chloramphenicol.抗菌抗生素红霉素和氯霉素诱导酿酒酵母细胞质小菌落突变
Mol Gen Genet. 1971;111(3):209-23. doi: 10.1007/BF00433106.
6
The biogenesis of mitochondria in Saccharomyces cerevisiae. A comparison between cytoplasmic respiratory-deficient mutant yeast and chlormaphenicol-inhibited wild type cells.酿酒酵母中线粒体的生物发生。细胞质呼吸缺陷型突变酵母与氯霉素抑制的野生型细胞之间的比较。
J Cell Biol. 1967 Jul;34(1):1-14. doi: 10.1083/jcb.34.1.1.
7
Relationship between cytoplasmic and mitochondrial apparatus of protein synthesis in yeast Saccharomyces cerevisiae.酿酒酵母中蛋白质合成的细胞质和线粒体机制之间的关系。
Mol Gen Genet. 1983;189(1):172-4. doi: 10.1007/BF00326073.
8
[Comparative characteristics of the activity of the protein synthesizing systems of wild-type cells and the cytoplasmic petite-mutant of the yeast Saccharomyces cerevisiae].[野生型细胞与酿酒酵母细胞质小菌落突变体蛋白质合成系统活性的比较特征]
Biokhimiia. 1973 Mar-Apr;38(2):277-82.
9
Biosynthesis of yeast mitochondria. Drug effects on the petite negative yeast kluyveromyces lactis.酵母线粒体的生物合成。药物对小菌落阴性酵母乳酸克鲁维酵母的影响。
Biochem Biophys Res Commun. 1971 Jul 16;44(2):396-402. doi: 10.1016/0006-291x(71)90613-9.
10
Effects of chloramphenicol isomers and erythromycin on enzyme and lipid synthesis induced by oxygen in wild-type and petite yeast.氯霉素异构体和红霉素对野生型及小菌落酵母中由氧诱导的酶合成和脂质合成的影响。
J Bacteriol. 1972 May;110(2):504-10. doi: 10.1128/jb.110.2.504-510.1972.

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1
Polypeptide binding to plastid envelopes during chloroplast development.质体发育过程中多肽与质体膜的结合。
Planta. 1976 Jan;129(2):127-31. doi: 10.1007/BF00390019.
2
Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport.酵母Sal1和Aac2载体通过一种不同于腺嘌呤核苷酸转运的活性对线粒体功能产生多效性影响。
Mol Genet Genomics. 2008 Jul;280(1):25-39. doi: 10.1007/s00438-008-0342-5. Epub 2008 Apr 23.
3
The mitochondrial nucleoid protein, Mgm101p, of Saccharomyces cerevisiae is involved in the maintenance of rho(+) and ori/rep-devoid petite genomes but is not required for hypersuppressive rho(-) mtDNA.酿酒酵母的线粒体类核蛋白Mgm101p参与维持ρ⁺和缺乏ori/rep的小基因组，但对于超抑制性ρ⁻线粒体DNA并非必需。
Genetics. 2002 Apr;160(4):1389-400. doi: 10.1093/genetics/160.4.1389.
4
Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae.高迁移率族蛋白Abf2p在酿酒酵母线粒体DNA分离、重组及拷贝数方面的功能
Genetics. 1998 Apr;148(4):1763-76. doi: 10.1093/genetics/148.4.1763.
5
Patterns of mitochondrial sorting in yeast zygotes.酵母合子中线粒体分选模式。
Mol Biol Cell. 1993 Jan;4(1):21-36. doi: 10.1091/mbc.4.1.21.
6
Analysis of rho mutability in Saccharomyces cerevisiae. II. Role of the mitochondrial protein synthesis.
Mol Gen Genet. 1980;177(4):589-95. doi: 10.1007/BF00272668.
7
Analysis of rho mutability in Saccharomyces cerevisiae. I. Effects of mmc and pet-ts alleles.酿酒酵母中rho突变性的分析。I. mmc和pet-ts等位基因的影响。
Mol Gen Genet. 1980;177(4):581-8. doi: 10.1007/BF00272667.
8
Induction of the cytoplasmic petite mutation in Saccharomyces cerevisiae by the antibacterial antibiotics erythromycin and chloramphenicol.抗菌抗生素红霉素和氯霉素诱导酿酒酵母细胞质小菌落突变
Mol Gen Genet. 1971;111(3):209-23. doi: 10.1007/BF00433106.
9
Cold-sensitive mutants in Aspergillus nidulans. I. Isolation and general characterisation.构巢曲霉中的冷敏感突变体。I. 分离与一般特征
Mol Gen Genet. 1974;134(2):99-113. doi: 10.1007/BF00268413.
10
Induction of cytoplasmic respiratory deficient mutants on yeast by the folic acid analogue, methotrexate. II. Genetic analysis of the methotrexate-induced petites.
Mol Gen Genet. 1973 Oct 16;126(1):71-4. doi: 10.1007/BF00333483.

本文引用的文献

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Temperature Dependence of the Spontaneous Mutation Rate to Respiration Deficiency in Saccharomyces.酿酒酵母中呼吸缺陷自发突变率的温度依赖性
Genetics. 1960 Feb;45(2):189-94. doi: 10.1093/genetics/45.2.189.
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EVIDENCE FOR TWO DISTINCT ASPECTS OF THE MECHANISM REGULATING CHROMOSOME REPLICATION IN ESCHERICHIA COLI.大肠杆菌中调控染色体复制机制的两个不同方面的证据。
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The biogenesis of mitochondria in Saccharomyces cerevisiae. A comparison between cytoplasmic respiratory-deficient mutant yeast and chlormaphenicol-inhibited wild type cells.酿酒酵母中线粒体的生物发生。细胞质呼吸缺陷型突变酵母与氯霉素抑制的野生型细胞之间的比较。
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In vivo differentiation of yeast cytoplasmic and mitochondrial protein synthesis with antibiotics.利用抗生素对酵母细胞质和线粒体蛋白质合成进行体内分化
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Mitochondrial DNA from yeast "petite" mutants: specific changes in buoyant density corresponding to different cytoplasmic mutations.酵母“小菌落”突变体的线粒体DNA：对应不同细胞质突变的浮力密度的特定变化。
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Cytoplasmic DNA from petite colonies of Saccharomyces cerevisiae: a hypothesis on the nature of the mutation.来自酿酒酵母小菌落的细胞质DNA：关于突变本质的一种假说。
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Preferential synthesis of yeast mitochondrial DNA in the absence of protein synthesis.在缺乏蛋白质合成的情况下酵母线粒体DNA的优先合成。
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10
The process of infection with bacteriophage phiX174. XXVII. Synthesis of a viral-specific chloramphenicol-resistant protein in phiX174-infected cells.噬菌体φX174的感染过程。XXVII. φX174感染细胞中病毒特异性氯霉素抗性蛋白的合成。
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低温和氯霉素诱导酿酒酵母冷敏感突变体的呼吸缺陷

Low temperature and chloramphenicol induction of respiratory deficiency in a cold-sensitive mutant of Saccharomyces cerevisiae.

作者信息

Weislogel P O, Butow R A

出版信息

Proc Natl Acad Sci U S A. 1970 Sep;67(1):52-8. doi: 10.1073/pnas.67.1.52.

DOI:10.1073/pnas.67.1.52
PMID:5272328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283165/
Abstract

A cold-sensitive mutant of a haploid strain of Saccharomyces cerevisiae has been isolated by selection for impaired growth at 18 degrees on nonfermentable carbon sources. Growth of the mutant on glucose or galactose at either 28 or 18 degrees is similar to that of the parental strain. The cold-sensitive strain is highly mutable to a cytoplasmic petite when grown at 18 degrees , or when grown at 28 degrees in the presence of 4 mg/ml of chloramphenicol. Cold sensitivity is not observed in the conversion of promitochondria to mitochondria. We conclude that mitochondrial protein synthesis is required for maintaining the stability of the mitochondrial genome.

摘要

通过在18摄氏度下于非发酵性碳源上筛选生长受损的菌株，分离出了酿酒酵母单倍体菌株的一个冷敏感突变体。该突变体在28摄氏度或18摄氏度下于葡萄糖或半乳糖上的生长情况与亲本菌株相似。当在18摄氏度下生长，或在28摄氏度下于4毫克/毫升氯霉素存在的情况下生长时，该冷敏感菌株极易突变为细胞质小菌落。在原线粒体向线粒体的转变过程中未观察到冷敏感性。我们得出结论，线粒体蛋白质合成对于维持线粒体基因组的稳定性是必需的。