Bullen B R, Ramsden C H, Kester R C
Curr Med Res Opin. 1979;6(4):244-8. doi: 10.1185/03007997909109430.
Cefamandole levels were measured in peripheral blood, and in skeletal muscle and subcutaneous fat samples taken from 20 patients during amputation of the leg for severe ischemia. Tissue samples were taken from both proximal and distal levels in the amputated limb. Cefamandole was administered as either a 2 g intravenous bolus given with induction of anaesthesia, or a combination of 1 g intramuscularly with the premedication plus 1 g intravenously with anaesthetic induction. Levels of cefamandole in serum and proximal muscle and fat samples were well above the minimum inhibitory concentrations required for most Gram-positive and Gram-negative organisms. Cefamandole levels in more distal samples were somewhat lower but still achieved therapeutic levels in most cases. Higher tissue levels of cefamandole were achieved when 2 g were given intravenously as a bolus.
在20例因严重缺血行腿部截肢手术的患者中，测定了外周血、骨骼肌和皮下脂肪样本中的头孢孟多水平。组织样本取自截肢肢体的近端和远端。头孢孟多给药方式为：麻醉诱导时静脉推注2g，或术前用药时肌肉注射1g加麻醉诱导时静脉注射1g。血清、近端肌肉和脂肪样本中的头孢孟多水平远高于大多数革兰氏阳性和革兰氏阴性菌所需的最低抑菌浓度。远端样本中的头孢孟多水平略低，但在大多数情况下仍能达到治疗水平。静脉推注2g时，头孢孟多在组织中的水平更高。
